T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type-1 cells
Interleukin 10 (IL-10)-producing regulatory T-cells (Tregs) play a central role in the maintenance of normal immune homeostasis. Treg cells include the well-characterized FOXP3+ subset as well as a FOXP3-negative CD4+ T-cell type that secretes IL-10 and …